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    探求雌激素�ξ�缩性阴道炎患者的治疗效果及其对阴道局部环境的影响。 体式格局 方便该院2015年6月―2017年6月收治的86例萎缩性阴道炎患者,按数字表法分为2组,对照组常规药物治疗,观察组在对照组条件下执行雌激素治疗,对照两组疗效。下场 观察组治疗总有效率97.67%,较着比对照组81.40%高(χ2=6.081,P=0.014);对照组与观察组治疗90 d与半年后的阴道健康健康评分分离为(8.13±1.74)分 vs (11.16±2.23)分,(8.26±1.84)分 vs(10.36±2.35)分较着高于治疗前,且观察组治疗后阴道健康评分高于对照组(t=7.025,P=0.000,t=4.613,P=0.000);治疗后两组患者阴道pH值与E2水平(5.63±0.26) vs (4.26±0.35),(50.26±10.14)pmol/L vs (57.26±10.02)pmol/L均优于治疗前,且观察组患者的阴道pH值与E2水平优于对照组(t=20.605,P=0.000,t=3.220,P=0.000);治疗期间无阴道出血等相关不良反应。论断 雌激素对萎缩性阴道炎患者的治疗效果明显,可使阴道局部环境明显改进。 [关键词] 萎缩性阴道炎;雌激素;阴道局部环境 [中图分类号] R4 [文献符号码] A [文章编号] 1674-0742(2018)07(b)-0095-03 Changes of Vaginal Environment after Estrogen Therapy in Patients with Atrophic Vaginitis SHI Zhi-qin Department of Family Planning Technical Service, Yangzhong Maternal and Child Health Hospital, Yangzhong, Jiangsu Province, 212200 China [Abstract] Objective This paper tries to explore the therapeutic effect of estrogen on patients with atrophic vaginitis and its effect on the local environment of vagina. Methods 86 patients with atrophic vaginitis treated in the hospital from June 2015 to June 2017 were convenient selected and divided into 2 groups according to the digital table method. The control group received routine drug treatment, while the observation group received estrogen treatment under the premise of the control group, and the efficacy of the two groups was compared. Results The observation group had a total effective rate of 97.67%, which was significantly higher than that of the control group (81.40%) (χ2=6.081, P=0.014). The vaginal health scores of the control group and the observation group after 90 days and six months of treatment were (8.13±1.74)points. The scores (11.16±2.23), (8.26±1.84)pomts vs (10.36±2.35)pomts were significantly higher than before treatment, and the vaginal health score of the observation group after treatment was higher than that of the control group (t=7.025, P=0.000, t=4.613). (P=0.000); after treatment, vaginal pH values and E2 levels (5.63±0.26) vs (4.26±0.35), (50.26±10.14)pmol/L vs(57.26±10.02) pmol/L were superior to the treatment. Before and in the observation group, the vaginal pH value and E2 level were better than those in the control group(t=20.605, P=0.000, t=3.220, P=0.000); there was no vaginal bleeding or other adverse reactions during the treatment period. Conclusion The therapeutic effect of estrogen on patients with atrophic vaginitis is significant, and the vaginal environment can be significantly improved. [Key words] Atrophic vaginitis; Estrogen; Vaginal local environment 萎缩性阴道炎次要是由雌激素短少,阴道局部环境涌现改变,导致致病菌大批繁殖或极易入侵导致的炎症,此病在绝经后主妇中非常稀有[1-2]。对该病治疗的关键为使阴道内微生态平衡有效恢复,对阴道局部免疫功效有效调节,补偿雌激素[3-4]。该研究方便选取该院2015年6月―2017年6月收治的86例萎缩性阴道炎患者,讨论了雌激素对萎缩性阴道炎患者的治疗效果及其对阴道局部环境的影响,现报道如下。 1 资料与体式格局 1.1 普通资料 方便选取该院收治的86例萎缩性阴道炎患者,局部患者都被迫签署知情同意书,研究经过伦理委员会的同意,遵照数字表法将其分为2组,对照组43例患者中,年龄最小48岁,年龄最大70岁,平均年龄(58.36±6.26)岁;绝经最短时间2年,最长时间9年,平均时间(5.56±0.26)年。观察组43例患者中,年龄最小49岁,年龄最大71岁,平均年龄(58.46±6.36)岁;绝经最短时间3年,最长时间8年,平均时间(5.63±0.32)年。两组患者绝经时间等根蒂根基资料的对照差距无统计学意义(P>0.05)。 1.2 体式格局 局部患者接受抗沾染治疗,治疗前举行细菌学检测,遵照药敏下场平正挑选抗菌药物,治疗时间90 d,治疗历程中禁止性生活。对照组予以复方甲硝唑栓剂(国药准字H19999218)治疗,1次/d,睡前对双手与外阴充足清洁,将栓剂在阴道深部置入,延续治疗7 d后停止给药。观察组在对照组条件下执行雌激素治疗,阴道局部采纳雌三醇乳膏(注册证号X20010242)治疗,0.5 g/次,1次/d,治疗7 d后遵照病情改进情形适当裁减剂量。 1.3 观察目的 对2组患者治疗先后阴道PH值、E2水平、阴道健康评分(评定内容有阴道清洁度、分泌物量以及引导舒展性等,分数越大,健康情况越好)及不良反应予以观察与统计。 1.4 疗效鉴定 根据《中药新药临床辅导准绳》《中国妇科临床研究》中的相关尺度予以评定:显效默示阴道灼热感等临床症状根蒂根基消逝,阴道分泌物的清洁度下降2级或以上;有效默示临床症状与人命体征较着缓解,阴道分泌物清洁度下降1级;有效默示症状与体征不改变,以至有加重的现象。 1.5 统计体式格局 经过历程SPSS 21.0统计学软件,计量资料如阴道健康评分等默示用(x±s),用t检讨,计数资料如治疗效果等默示用[n(%)],挑选χ2检讨,P0.05);治疗90 d与半年后的阴道健康健康评分较着高于治疗前,且观察组治疗后阴道健康评分高于对照组,(P0.05);治疗后两组患者阴道pH值与E2水平均优于治疗前,且观察组患者的阴道pH值与E2水平优于对照组(P

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